villmann lab

People

Prof Dr. Carmen Villmann

Institute of Clinical Neurobiology, University Hospital of Würzburg

villmann_c@ukw.de

Versbacherstr. 5, 97078 Würzburg

+49 931 201 44035

www.neurobiologie.uk-wuerzburg.de

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Research

Research

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Publications (selected list)

Janzen D, Slavik B, Zehe M, Sotriffer C, Loos HM, Buettner A, Villmann C. Sesquiterpenes and sesquiterpenoids harbor modulatory allosteric potential and affect inhibitory GABAA receptor function in vitro. J Neurochem. 2021 Jul 15. doi: 10.1111/jnc.15469. Epub ahead of print. PMID: 34263932.

Kasaragod VB, Pacios-Michelena A, Schaefer N, Zheng F, Bader N, Alzheimer C, Villmann C, Schindelin H. Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33235-33245. doi: 10.1073/pnas.2008695117. Epub 2020 Dec 14. PMID: 33318193; PMCID: PMC7777086.

Zlotos DP, Abdelmalek CM, Botros LS, Banoub MM, Mandour YM, Breitinger U, El Nady A, Breitinger HG, Sotriffer C, Villmann C, Jensen AA, Holzgrabe U. C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. J Nat Prod. 2021 Feb 26;84(2):382-394. doi: 10.1021/acs.jnatprod.0c01030. Epub 2021 Feb 17. PMID: 33596384.

Deckert J, Weber H, Villmann C, ..., Romanos M, Domschke K, Pauli P, Reif A (2017). GLRB allelic variation associated with agoraphobic cognitions, increased startle response, and fear network activation: a potential neurogenetic pathway to panic disorder. Mol Psychiatry doi: 10.1038/mp.2017.2.

Doppler K, Appeltshauser L, Villmann C, Martin C, Peles E, Krämer HH, Haarmann A, Buttmann M, Sommer C (2016). Auto-antobodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain 139:2617–2630.

Atak S, Langlhofer G, Schaefer N, Kessler D, Delto C, Schindelin H, Villmann C (2015). Disturbances of Ligand Potency and enhanced degradation of the human glycine receptor at affected positions G160 and T162 originally identified in patients suffering from Hyperekplexia. Front Mol Neurosci 8:79.


Doppler K, Appeltshauser L, Wilhelmi K, Villmann C, Dib-Hajj SD, Waxman SG, Mäurer M, Weishaupt A, Sommer C (2015). Severe destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 auto-antibodies. J Neurol Neurosurg Psychiatry 86:720–728.


Langlhofer G, Janzen D, Meiselbach H, Villmann C (2015). Length of the TM3-4 loop of the glycine receptor modulates receptor desensitization. Neurosci Lett 600:176–181.


Schaefer N, Kluck CJ, Price KL, Meiselbach H, Vornberger N, Schwarzinger S, Hartmann S, Langlhofer G, Schulz S, Schlegel N, …, Villmann C (2015). Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia. J Neurosci 35:422–437.


Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, Sticht H, Breitinger HG, Becker CM, Villmann C (2014). Single Expressed Glycine Receptor Domains Reconstitute Functional Ion Channels without Subunit-Specific Desensitization Behavior. J Biol Chem 289:29135–29147.


Unterer B, Becker CM, Villmann C (2012). The importance of TM3-4 loop subdomains for functional reconstitution of glycine receptors by independent domains. J Biol Chem 287:39205–39215.


Coras R, Siebzehnrubl FA, Pauli E, Huttner HB, Njunting M, Kobow K, Villmann C, Hahnen E, Neuhuber W, Weigel D, Buchfelder M, Stefan H, Steindler DA, Blümcke I (2010). Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans epilepsy. Brain 133:3359–3372.


Villmann C, Oertel J, Ma-Högemeier ZL, Hollmann M, Sprengel R, Becker K, Breitinger HG, Becker CM (2009). Functional complementation of Glra1spd-ot, a glycine receptor subunit mutant, by independently expressed C-terminal domains. J Neurosci 29:2440–2452.