Neuronal signaling is facilitated by specialized membrane proteins called ion channels. Ion channels are permeable for distinct ions that passively flow down their electrochemical gradient across neuronal membranes. Our group is interested in neuronal inhibition in the central nervous system. Inhibitory neurotransmission involves inhibitory ion channels, e.g glycine and GABAA receptors. These receptors are ligand-gated and belong to the superfamily of Cys-loop receptors. Disturbances in glycinergic signal transmission pathways are associated with neuromotor disorders (Startle disease, hyperekplexia), pain, autism, and panic disorders. Hence, glycine receptors are target molecules of therapeutic drugs. We aim at cellular and molecular mechanisms of receptor trafficking, synaptic localization, receptor functionality characterized by patch-clamp electrophysiology. To bridge molecular and in vivo approaches, we analyze mouse models at the behavioral, cellular and functional levels.