siren lab


Prof. Dr. Anna-Leena Sirén

Department of Neurosurgery, University Hospital of Würzburg

Josef-Schneider-Str. 11, 97080 Würzburg

+49 931 201 24579

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Publications (selected list)

Hassouna I, Ott C, Wüstefeld L, Offen N, Neher R, Mitkovski M, Winkler D; Sperling S, Fries L, Goebbels S, ..., Sirén A-L, Ehrenreich H (2016). Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus. Mol Psychiatry 21:1752–1767.

Hopp S, Albert-Weissenberger C, Mencl S, Bieber M, Schumann, MK, Stetter C, Nieswandt B, Schmidt PM, Monoranu C, Alafuzoff I, Marklund N, Nolte MW, Sirén A-L, Kleinschnitz C (2016). Targeting coagulation factor XII as a novel therapeutic option in brain trauma. Ann Neurol 79:970–982.

Israel I, Ohsiek A, Al-Momani E, Albert-Weissenberger C, Stetter C, Mencl S, Buck AK, Kleinschnitz C, Samnick S, Sirén A-L (2016). Combined [18F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice. J Neuroinflammation 13:140.

Albert-Weissenberger C, Stetter C, Meuth S, Göbel K, Bader M, Sirén A-L*, Kleinschnitz C* (2012). Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. J Cereb Blood Flow Metab 32:1747–1756. *equal contribution.

Byts N, Samoylenko A, Fasshauer T, Ivanisevic M, Hennighausen L, Ehrenreich H, Sirén AL (2008). Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. Cell Death Differ 15:783–792.

Sirén A-L, Radyushkin K, Boretius S, Kämmer D, Riechers C-C, Natt O, Sargin D, Watanabe T, Sperling S, Michaelis T, Price J, Maier B, Frahm J, Ehrenreich H (2006). Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin. Brain 129:480–489.

Ehrenreich H, Hasselblatt M, Knerlich F, von Ahsen N, Jacob S, Sperling S, Woldt H, Vehmeyer K, Nave K-A, Sirén A-L (2005). A hematopoietic growth factor, thrombopoietin, has a pro-apoptotic role in the brain. Proc Natl Acad Sci USA 102:862–867.


Ehrenreich H, Degner D, Meller J, Brines M, Béhé M, Hasselblatt M, Woldt H, Falkai M, Knerlich F, Jacob S, von Ahsen N, Maier W, Brück W, Rüther E, Cerami A, Becker W, Sirén A-L (2004). Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry 9:42–54.

Sirén A-L, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P (2001). Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98:4044–4049.

Sirén A-L, Knerlich F, Poser W, Gleiter CH, Brück W, Ehrenreich H (2001). Erythropoietin and erythropoietin receptor expression in human ischemic/hypoxic brain. Acta Neuropathol 101:271–276.