left to right: Hazem DeBakey, Jonas Roothans, Julia Krapp, Robert C. Nickl, Benedikt Weigl, Regina Pistorius, Martin M. Reich, Leonie Massa, Anne Grossmann, Maria Leberzammer, Florian Lange, Tobias Binder.
Martin M. Reich, MD
Department of Neurology
University of Wuerzburg
97080 Wuerzburg, Germany
Phone: 0049 931 201 24621
Our multidisciplinary junior group tries to answer clinical questions related to deep brain stimulation and the pathophysiology of movement disorders through computer visualisation and modelling. The therapy option of deep brain stimulation arose two decades ago and is established for diseases such as Tremor, Parkinson’s disease and Dystonia. Nevertheless, most of the mechanisms of this local therapy are superficially understood and patients show great outcome variability.
We are strongly motivated by these challenges, which we often pick up while clinics. We aim to clarify various neuromodulation mechanisms and to disentangle brain network effects. We visualise the local current distribution by using ‘Volume of tissue activated’-computer models and showing the network effect with functional and structural MR images or with multiple PET images. Our main goal after refining the pathophysiological models is to translate our research results back and improve daily DBS-patient care.
Reich et al. (2015) Model for action potential explain mechanism of stimulation at short pulse duration by focusing on excitation of smaller myelinated axons near the electrode and a steeper falloff for activation of thick myelinated axons with increasing radius of current spread; in collaboration with Cameron C. McIntyre (Cleveland; US).
Horn, Reich et al. (2017) Effective STN DBS for PD is associated with a specific connectivity profile that can predict clinical outcome across independent cohorts. This prediction does not require specialized imaging in PD patients themselves; in collaboration with Michael Fox (Boston, US).
Publications (selected list)
Reich, M. M., et al. (2015). Short pulse width widens the therapeutic window of subthalamic neurostimulation., Ann Clin Transl Neurol 2(4): 427-432.
Reich, M. M., et al. (2016). "Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy?" Brain 139: 2948-2956.
Reich, M. M., et al. (2017). "Reply: Clinical approach to delayed-onset cerebellar impairment following deep brain stimulation for tremor." Brain 140(5), e28–e28.
Horn, A., Reich, M. M., et al. (2017). "Connectivity Predicts deep brain stimulation outcome in Parkinson disease." Ann Neurol 82(1): 67-78.