martini lab


Prof. Rudolf Martini

Department of Neurology, University Hospital of Würzburg

Josef-Schneider-Str. 11, 97080 Würzburg

+49 931 201 23268

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Publications (selected list)

Groh J, Friedman HC, Orel N, Ip CW, Fischer S, Spahn I, Schaffner E, Horner M, Stadler D, Buttmann M, …, Martini R (2016). Pathogenic inflammation in the CNS of mice carrying human PLP1 mutations. Hum Mol Genet 25:4686–4702.

Groh J, Basu R, Stanley ER, Martini R (2016) Cell-surface and secreted isoforms of CSF-1 exert opposing roles in macrophage-mediated neural damage in Cx32-deficient mice. J Neurosci 36: 1890 –1901.

Groh J, Ribechini E, Stadler D, Schilling T, Lutz MB, Martini R (2016) Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease. Glia, 64: 792-809.

Klein D, Patzko A, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R (2015). Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice. Brain 138:3193–3205.


Groh J, Kuhl TG, Ip CW, Nelvagal HR, Sri S, Duckett S, Mirza M, Langmann T, Cooper JD, Martini R (2013). Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis. Brain 136:1083–1101.


Groh J, Weis J, Zieger H, Stanley ER, Heuer H, Martini R (2012). Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X. Brain 135:88–104.

Groh J, Heinl, K, Kohl B, Wessig C, Greeske J, Fischer S, Martini R (2010). Attenuation of MCP-1/CCL2 expression ameliorates neuropathy in a mouse model for Charcot-Marie-Tooth 1X. Hum Mol Genet 19:3530–3543.

Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R (2006). Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J Neurosci 26:8206–8216.

Kobsar I, Berghoff M, Samsam M, Wessig C, Mäurer M, Toyka KV, Martini R (2003). Preserved myelin integrity and reduced axonopathy in connexin32 deficient mice lacking RAG-1. Brain 126:804–813.

Carenini S, Mäurer M, Werner A, Blazyca H, Toyka KV, Schmid CD, Raivich G, Martini R (2001). The role of macrophages in demyelinating peripheral nervous system of mice heterozygously
deficient in P0. J Cell Biol 152:301–308.