lesch lab


Prof. Dr. Klaus-Peter Lesch

Division of Molecular Psychiatry, University Hospital of Würzburg


Margarete-Höppel-Platz 1, 97080 Würzburg

+49 931 201 77600


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Publications (selected list)

Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Ripke S, Lee PH, Neale BM, Nurnberger JI, Santangelo S, Sullivan PF, Perlis RH, Purcell SM, ..., Lesch KP, …, Craddock N, Kendler K (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381:1371–1379.

Schartl M, Walter RB, Shen Y, Garcian T, Catchen J, Amores A, Braasch I, Chalopin D, Volff JN, Lesch KP et al (2013). The genome of the platyfish, Xiphophorus maculatus provides insights into evolutionary adaption and several complex traits. Nat Genetics 45:567–572.

Lange M, Norton W, Coolen M, Chaminade M, Merker S, Proft F, Schmitt A, Vernier P, Lesch KP, Bally-Cuif L (2012). The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Mol Psychiatry 17:946–954.

Williams NM, Franke B, Mick E, Anney RJ, Freitag CM, Gill M, Thapar A, O'Donovan MC, Owen MJ, Holmans P, ..., Lesch KP, Faraone SV (2012). Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry 169:195–204.

Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PM, Zhang H, Kim CE, Robinson R, ..., Lesch KP, ..., Faraone SV, Hakonarson H (2011). Genome wide copy number variation study associates metabotropic glutamate receptor genes with attention deficit hyperactivity disorder. Nat Genet 44:78–84.

Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Walitza S, Shoichet S, Dempfle A, ..., Ropers HH, Ullmann R (2011). Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry 16:491–503.

Reif A, Jacob CP, Rujescu D, Herterich S, Lang S; Gutknecht L, Baehne C; Strobel A, Freitag CM, Giegling I, ..., Ehlis AC, Lesch KP (2009). Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans. Arch Gen Psychiatry 66:41–50.

Romanos M, Freitag C, Jacob C, Craig DW, Dempfle A, Nguyen T, Halperin R, Walitza S, Renner TJ, Seitz C, ..., Stephan DA, Lesch KP (2008). Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12. Mol Psychiatry 13:522–530.

Reif A, Fritzen S, Finger M, Strobel A, Lauer M, Schmitt A, Lesch KP (2006). Neural stem cell proliferation is decreased in schizophrenia, but not in depression. Mol Psychiatry 11:514–522.

Reif A, Herterich S, Strobel A, Ehlis AC, Saur D, Jacob CP, Wienker T, Töpner T, Fritzen S, Walter U, Schmitt A, Fallgatter AJ, Lesch KP (2006). A neuronal nitric oxide synthase (NOSI) haplotype associated with schizophrenia modifies prefrontal cortex function. Mol Psychiatry 11:286–300.

© 2021 by Philip Tovote

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last update: 05/05/2021