Publications (selected list)
Brumber J. Küsters S, Al-Momani E, et al, Isaias IU. Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecularimaging study. Annals of Clinical and Translational Neurology. 2017, in press.
Pozzi NG, Arnulfo G, Canessa A, et al, Isaias IU. Distinctive neuronal firing patterns in subterritories of the subthalamic nucleus. Clin Neurophysiol. 2016;127:3387-3393.
Reich MM, Brumberg J, Pozzi NG, et al, Isaias IU. Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy? Brain 2016, in press.
Dipaola M, Pavan EE, Cattaneo A, et al, Isaias IU. Mechanical Energy Recovery during Walking in Patients with Parkinson Disease. PLoS One 2016;11:e0156420.
Isaias IU, Trujillo P, Summers P, et al. Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease. Front Aging Neurosci. 2016;8:196.
Canessa A, Pozzi NG, Arnulfo G, et al, Isaias IU. Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease. Front Hum Neurosci. 2016;10:611.
Mencacci NE, Isaias IU, Reich MM, et al. Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain. 2014;137:2480-92.
Isaias IU, Volkmann J, Marzegan A, et al. The influence of dopaminergic striatal innervation on upper limb locomotor synergies. PLoS One. 2012;7:e51464.
Isaias IU, Marzegan A, Pezzoli G, et al. A role for locus coeruleus in Parkinson tremor. Front Hum Neurosci. 2011;5:179.
Isaias IU, Moisello C, Marotta G, et al. Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill. J Neurosci. 2011;31:14458-62.
Parkinson’s disease exhibits considerable heterogeneity in clinical presentation and progression. This suggests potent neuroprotective and compensatory mechanisms, which could possibly serve for disease-modifying therapies, as well as the care of parkinsonian patients. To this regards, we have a strong neurobiological interest and focus on the contribution of the noradrenergic system to the pathology of Parkinson’s disease.
The annual incidence of falls amongst patients with Parkinson’s disease is up to 60% and may lead to injuries, loss of independence, institutionalization and increased mortality. Currently, no treatment is particularly efficient and fall prediction and prevention remain elusive. Our research combines molecular brain imaging studies with simultaneous biomechanical measurements and cortical and deep brain recordings to elucidate posture and locomotion disturbances in parkinsonian patients.
Levodopa-related dyskinesias are unintended, involuntary and uncontrollable movements that emerge in the vast majority of parkinsonian patients and can interfere dramatically with patients’ life. We are investigating the molecular and neurophysiological mechanisms of dyskinesias with multiple molecular imaging studies and neurophysiological recordings (e.g., navigated transcranial magnetic stimulation combined with high-density electroencephalography).