blum Group

People

People trained and working in our group (August 2017). Left to right: Nina Scheffler (Master student, Biology), Linda Bieniussa (MSc, scientific assistance), Yi Wang (Master student, Translational Neuroscience), Manju Sasi (doctoral researcher, GSLS fellowship), behind: Dennis Segebarth (doctoral researcher), Rohini Gupta (doctoral researcher, GSLS fellowship), behind: Cora Rüdt von Collenberg (doctoral researcher), in the front: Nastaran Madani Esfahani (student, Translational Neuroscience and scientific assistance), Corinna Martin (doctoral researcher), Robert Blum (group leader).

PD Dr. Robert Blum

Institute of Clinical Neurobiology, University Hospital of Würzburg

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Publications (selected list)

Hofmann L, Hose D, Griesshammer A, Blum R, Doring F, Dib-Hajj S, Waxman S, Sommer C, Wischeyer E, Uceyler N (2018) Characterization of small fiber pathology in a mouse model of Fabry disease. Elife 7(e39300). doi: 10.7554/eLife.39300.001

Martin C, Stoffer C, Mohammadi M, Hugo J, Leipold E, Oehler B, Rittner HL, Blum R (2018) NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions. Front Mol Neurosci 11(7):7. doi: 10.3389/fnmol.2018.00007

Mohammadi M, Oehler B, Kloka J, Martin C, Brack A, Blum R, Rittner HL (2018) Antinociception by the anti-oxidized phospholipid antibody E06. Br J Pharmacol 175(14):2940-55. doi: 10.1111/bph.14340

Prada J, Sasi M, Martin C, Jablonka S, Dandekar T, Blum R (2018). An open source tool for automatic spatiotemporal assessment of calcium transients and local 'signal-close-to-noise' activity in calcium imaging data. PLoS Comput Biol 14(3):e1006054. dli: 10.1371/journal.pcbi.1006054

Sasi M, Vignoli B, Canossa M, Blum R (2017) Neurobiology of local and intercellular BDNF signaling. Pflügers Archiv : European journal of physiology 469: 593-610, doi:10.1007/s00424-017-1964-4

 

Oehler B, Kistner K, Martin C, Schiller J, Mayer R, Mohammadi M, Sauer RS, Filipovic MR, Nieto FR, Kloka J, Pflucke D, Hill K, Schaefer M, Malcangio M, Reeh PW, Brack A*, Blum R*, Rittner HL* (2017) Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation. Scientific reports 7: 5447, doi:10.1038/s41598-017-05348-3.

 

Moradi M, Sivadasan R, Saal L, Lüningschror P, Dombert B, Rathod RJ, Dieterich DC, Blum R, Sendtner M (2017) Differential roles of alpha-, beta-, and gamma-actin in axon growth and collateral branch formation in motoneurons. The Journal of cell biology 216: 793-814, doi:10.1083/jcb.201604117

 

Deckert J, Weber H, Villmann C, Lonsdorf TB, Richter J, Andreatta M, Arias-Vasquez A, Hommers L, Kent L, Schartner C, Cichon S, Wolf C, Schaefer N, von Collenberg CR, Wachter B, Blum R, Schumann D, Scharfenort R, Schumacher J, Forstner AJ, Baumann C, Schiele MA, Notzon S, Zwanzger P, Janzing JG, Galesloot T, Kiemeney LA, Gajewska A, Glotzbach-Schoon E, Muhlberger A, Alpers G, Fydrich T, Fehm L, Gerlach AL, Kircher T, Lang T, Strohle A, Arolt V, Wittchen HU, Kalisch R, Buchel C, Hamm A, Nothen MM, Romanos M, Domschke K, Pauli P, Reif A (2017) GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder. Mol Psychiatry, doi:10.1038/mp.2017.2

 

Yadav P, Selvaraj BT, Bender FL, Behringer M, Moradi M, Sivadasan R, Dombert B, Blum R, Asan E, Sauer M, Julien JP, Sendtner M (2016) Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling. Acta neuropathologica 132: 93-110, doi:10.1007/s00401-016-1564-y

 

Vignoli B, Battistini G, Melani R, Blum R, Santi S, Berardi N, Canossa M (2016) Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention. Neuron 92: 873-887, doi:10.1016/j.neuron.2016.09.031

 

Schmitt D, Funk N, Blum R, Asan E, Andersen L, Rulicke T, Sendtner M, Buchner E (2016) Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons. Histochemistry and cell biology 146: 489-512, doi:10.1007/s00418-016-1457-0

 

Samtleben S, Wachter B, Blum R (2015) Store-operated calcium entry compensates fast ER calcium loss in resting hippocampal neurons. Cell calcium 58: 147-159, doi:10.1016/j.ceca.2015.04.002

 

Blum R, Lesch KP (2015) Parkinson's disease, anxious depression and serotonin--zooming in on hippocampal neurogenesis. J Neurochem 135: 441-444, doi:10.1111/jnc.13278

 

Andreska T, Aufmkolk S, Sauer M*, Blum R* (2014) High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Frontiers in cellular neuroscience 8: 107, doi:10.3389/fncel.2014.00107

 

Wetzel A, Jablonka S, Blum R (2013) Cell-autonomous axon growth of young motoneurons is triggered by a voltage-gated sodium channel. Channels (Austin) 7: 51-56, doi:10.4161/chan.23153

 

Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (2013) Trnp1 regulates expansion and folding of the Mammalian cerebral cortex by control of radial glial fate. Cell 153: 535-549, doi:10.1016/j.cell.2013.03.027

 

Samtleben S, Jaepel J, Fecher C, Andreska T, Rehberg M, Blum R (2013) Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED). Journal of visualized experiments : JoVE 75: e50317, doi:10.3791/50317

 

Pfeiffer V, Götz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR (2013) Ablation of BRaf Impairs Neuronal Differentiation in the Postnatal Hippocampus and Cerebellum. PloS one 8: e58259, doi:10.1371/journal.pone.0058259

 

Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stodberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hubner CA, Kurth I (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nature genetics 45: 1399-1404, doi:10.1038/ng.2767

 

Subramanian N, Wetzel A, Dombert B, Yadav P, Havlicek S, Jablonka S, Nassar MA, Blum R*, Sendtner M* (2012) Role of Na(v)1.9 in activity-dependent axon growth in motoneurons. Human molecular genetics 21: 3655-3667, doi:10.1093/hmg/dds195

 

Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan O, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalie A, Zimmermann R (2012) BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. The EMBO journal 31: 3282-3296, doi:10.1038/emboj.2012.189

 

Rathod R, Havlicek S, Frank N, Blum R, Sendtner M (2012) Laminin induced local axonal translation of beta-actin mRNA is impaired in SMN-deficient motoneurons. Histochemistry and cell biology 138: 737-748, doi:10.1007/s00418-012-0989-1

 

Jaepel J, Blum R (2011) Capturing ER calcium dynamics. Eur J Cell Biol 90: 613-619, doi:10.1016/j.ejcb.2011.02.010

 

Blum R, Heinrich C, Sanchez R, Lepier A, Gundelfinger ED, Berninger B, Götz M (2011) Neuronal network formation from reprogrammed early postnatal rat cortical glial cells. Cereb Cortex 21: 413-424, doi:10.1093/cercor/bhq107

Research

Project 1:

Calcium signals induced by the neurotrophin brain-derived neurotrophic factor (BDNF) are critically involved in synaptic plasticity, learning and memory. However, the interplay of BDNF-induced calcium signaling cascades is not accurately defined. These signaling cascades include ER calcium store release events, fast calcium influx events, and the modulation of neuronal excitability. The aim of this project is to define the temporal and spatial interplay of BDNF-dependent calcium signaling in the hippocampus and to characterize the underlying homeostatic calcium fluxes. The purpose is the identification of target molecules for a mechanistic-based therapy to treat psychiatric and neurodegenerative diseases. Funded by the DFG.

 

Project 2:

This project will investigate how hippocampal mossy fibre BDNF affects the mossy fibre to CA3 microcircuit in the stratum lucidum to modulate fear behavior. The mossy fibre projections in stratum lucidum influence a microcircuit involved in precision of memory and context pattern separation. Notably, MF synapses store high amounts BDNF, thus raising the question whether local BDNF function at this synapse affects fear memory, fear circuit properties, and anxiety-like behavior. The project shall contribute to a better understanding of signaling mechanisms underlying mossy fibre function in contextual fear regulation and fear generalization. Funded by the DFG.

 

Project 3:

In a collaboration with HL. Rittner and B. Oehler from the Department of Anesthesiology we recently described that oxidized phospholipids are endogenous pain-inducing irritants. Here, TRP ion channels were identified as mediators of oxidized phospholipid function. Notably, we identified two prototypical therapeutics interfering with oxidized phospholipid function. In this project we investigate how these intrinsic irritants excite primary sensory neurons. The overall aim is to better understand pain resolution through compounds against oxidized phospholipids. Funded by the IZKF Würzburg.

© 2019 by Philip Tovote

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last update: 10/29/2019